A recent study suggests that individuals who come off blockbuster GLP-1 drugs like Wegovy and Mounjaro can put back on lost weight much more quickly than those who stop conventional lifestyle plans.
Findings released in a leading medical journal shows that while overweight individuals can lose substantial amounts of their body weight while on the medication, the weight returns at an estimated rate of nearly a kilo each month once they quit.
"Users purchasing these medications need to be informed of the danger of rapid rebound weight gain when the therapy is stopped," stated lead investigator Dr. Susan Jebb.
That rate of regain suggests a return to original mass in about a year and a half.
Comparing Treatments
The analysis, which reviewed 37 of trials involving thousands of participants, compared the results of the injectable medications with older methods.
Scientists emphasize that individuals who lose weight through dieting usually see a more gradual weight regain—approximately 100 grams monthly—post-intervention.
Understanding the Quick Regain
Nutrition scientists suggest the mechanism of the drugs is key to understanding the heightened rebound.
The injections mimic a natural hormone called glucagon-like peptide-1, which moderates feelings of fullness.
"Artificially providing the hormone levels several times higher than the body's typical production might result in the body to generate a reduced amount of its endogenous hormone, and may also lessen responsiveness to its effects," explained Dr. Adam Collins, a nutrition specialist.
"Withdrawal of this GLP-1 'fix' means hunger is uncontrolled, making excessive eating a significant risk."
A Chronic Issue?
Health authorities suggest the jabs for individuals with weight-linked health risks, accompanied by recommended lifestyle changes.
Many experts contend that, given the significant potential of weight regain, the therapy is often ongoing.
This opinion is reinforced by drug manufacturers, who note that the findings "underscore the long-term character of excess weight," similar to managing conditions like high blood pressure.
Patient Testimonies
People who have discontinued the jabs explain a sudden resurgence of hunger.
"It felt as if something that goes on and you become starving," recalled a patient.
This challenge is compounded if individuals have not developed permanent lifestyle or habit modifications during treatment.
Significant Use
Recent estimates suggest that millions of adults in the UK have tried weight-loss jabs in the past year, with interest remaining high.
- Use is greater among women compared to males.
- The 40s and 50s age group shows the highest usage rates.
- A large proportion access the medications through private prescriptions rather than the NHS.
Ultimately, clinicians caution that while GLP-1 drugs are effective agents for weight loss, they are not a standalone fix and lasting health benefits relies on ongoing behavioural support.
